UNIVERSITAS AIRLANGGA



Detail Article

Majalah Farmasi Airlangga (Airlangga Journal of Pharmacy)

ISSN 0852-1050

Vol. 7 / No. 2 / Published : 2009-10

Order : 1, and page :1 - 4

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Original Article :

effect of  u-50,488 h on the development of drug craving behavioral and protection of morphological change in prefrontal cortex, thalamus and amygdale of the mice (mus musculus)  in the morphine-induced dependence

Author :

  1. Aniek Setiya Budiatin*1
  2. Twoti Dika Parmanasari*2
  3. Uswatun Khasanah*3
  4. Junaidi Khotib*4
  1. Dosen Fakultas Farmasi
  2. Mahasiswa Fakultas Farmasi
  3. Dosen Pasca Sarjana
  4. Dosen Fakultas Farmasi

Abstract :

Repeated treatment of morphine produces several change in brain and behavior that far outlast their initial neuropharmacological effects. The nature of persistent drug-induced neural plasticity is interested because it is thought to contribute to the development of drug dependency and addiction. The purpose of this study was designed to investigate the effect  administration of a selective κ-opioid reseptor agonist  (U-50,488H) on rewarding effect associated with morphine in mice and the neuron morphological change on the several brain region (PFC,thalamus and basolateral amygdala). An unbiased conditioned place preference was developed to evaluate the rewarding effect of morphine in this animals. Drug craving model was induced by subcutant injection of morphine at 3 mg/kg  BW( based on previous study) once a day for six altermately days. Various doses U-50,488H ( 0.1 mg/kg; 1.0 mg/kg; 3mg/kg BW) was administered by subcutant injection pretreatment  with morphine. The data showed that rewarding effect of morphine was strongly suppressed by pretreatment U-50,488H and significantly attenuated at dose 0.1 mg/kg (F (4.48) = 14.024;p<0.05). The brain tissue was harvested on day 11 and sliced stereotaxically on PTC, thalamus and basolateral amygdale. The slicing was stained with routine histology staining, hematoxyllin eosin for morphological qualitative analysis. The result showed that U-50,488H restore neuron morphology in the several brain region (PFC, thalamus and basolateral amygdale) induced by morphine

Keyword :

Conditioned Place Preference; drug craving; morphine; PFC, thalamus and basolateral amygdale; U-50, 488H,


References :

Bardo, M.T and Bevins, R.A,(2000) Conditioned place preference: what does it add to our preclinical understanding of drug reward Vol.153 No.1, p.31-43 : Psychopharmacology

Narita, M., Khotib, J., Suzuki, M., Ozaki, S., Yajima, Y and Suzuki, T.,(2003) Heterologous μ-opioid receptor adaptation by repeated stimulation of κ-opioid receptor:up-regulation of G-proteion activation and antinociception Vol. 85, p.1171-1179 : Journal of Neurochemistry

Prisinzano, T.E., Tidgewell, K and Harding, W.H,(2005) k-Opioids as Potential Treatment for Stimulant Dependence vol.7 No.3, p.92-99 : The AAPS Journal





Archive Article

Cover Media Content

Volume : 7 / No. : 2 / Pub. : 2009-10
  1. Effect Of  U-50,488 H On The Development Of Drug Craving Behavioral And Protection Of Morphological Change In Prefrontal Cortex, Thalamus And Amygdale Of The Mice (mus Musculus)  In The Morphine-induced Dependence
  2. Efek Agonis Selektif Reseptor Opioid Kappa U-50,488h Pada Perubahan Morfologi Neuronal Refrontal Cortex (pfc) Dan Nucleus Accumbens (nac) Mencit (mus Musculus) Yang Mengalami Ketergantungan Morfin
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